Invasive molecular prenatal diagnosis of alpha and beta thalassemia among Hakka pregnant women
نویسندگان
چکیده
منابع مشابه
Prenatal Diagnosis and Frequency Determination of alpha and beta Thalassemia, S, D, C, and H Hemoglobinopathies Globin Mutational Genes Aanalysis among Voluntary Couples from Ahvaz
Background: The aim of this perspective study was to assess the frequency of hemoglobinopathy mutational genes among voluntary hemoglobinopathy carrier couples-to-be referred to thalassemia center, Shafa hospital, affiliated to Ahvaz Jondidishapur University of Medical Sciences (AJUOMS), during their first trimester of pregnancy for genetic screening and counseling for prenatal diagnosis (PND)....
متن کاملMolecular Basis and Prenatal Diagnosis of 9 - Thalassemia By Haig
Blood (print ISSN 0006-4971, online ISSN 1528-0020), is published weekly by only. The American The J Society ournal of of Hematology VOL 72, NO 4 OCTOBER 1988 THALASSEMIA is an autosomal recessive disease characterized by hypochromic, hemolytic anemia, and dependence on blood transfusions to sustain life.' Even with chelation therapy to remove excess iron stores, the life expectancy in classic ...
متن کاملThe molecular basis of beta-thalassemia in Lebanon: application to prenatal diagnosis.
A study of the molecular lesions of beta-thalassemia in Lebanon revealed the presence of eight different mutations in 25 patients with Cooley's anemia. The IVS1 position 110 mutation predominated with a frequency of 62% and was almost invariably associated with Mediterranean chromosome haplotype I. Five other mutations commonly found in the Mediterranean area occurred with frequencies of 2% to ...
متن کاملMOLECULAR STUDIES ON THE DIST RIBUTION OF β - THALASSEMIA IN IRAN: THE BASIS FOR PRENATAL DIAGNOSIS
By application of modern recombinant DNA technology, especially the polymerase chain reaction (PCR)/dot-blot hybridization techniques, we have investigated the molecular basis of β-thalassemia from four different regions of Iran: central, south-east, south and north. In this study, the DNA samples were isolated from patients and for the identification of the mutations, the 6 oligonucleotide...
متن کاملprenatal diagnosis and frequency determination of alpha and beta thalassemia, s, d, c, and h hemoglobinopathies globin mutational genes aanalysis among voluntary couples from ahvaz
background: the aim of this perspective study was to assess the frequency of hemoglobinopathy mutational genes among voluntary hemoglobinopathy carrier couples-to-be referred to thalassemia center, shafa hospital, affiliated to ahvaz jondidishapur university of medical sciences (ajuoms), during their first trimester of pregnancy for genetic screening and counseling for prenatal diagnosis (pnd)....
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ژورنال
عنوان ژورنال: Medicine
سال: 2018
ISSN: 0025-7974,1536-5964
DOI: 10.1097/md.0000000000013557